Publications List

Independent Career

31) H. Guo, C. C. J. Loh* Sci. Bull. 2024, 69, 3308-3310. (invited contribution to highlight Prof. Dawen Niu's work)

Merging Radical Catalysis and Noncovalent Stereocontrol Concepts to forge native O-glycosidic linkages.

30) H. Guo, D. Tan, C. Merten, C. C. J. Loh* Angew. Chem. Int. Ed. 2024, DOI: 10.1002/anie202409530

Enantioconvergent and Site-Selective Etherification of Carbohydrate Polyols through Chiral Copper Radical Catalysis

29) W. Ma, A. Schmidt, C. Strohmann, C. C. J. Loh* Angew. Chem. Int. Ed. 2024, 63, e202405706
(Selected as Hot Paper in Angew. Chem.)

Stereoselective Entry into α,α’-C-Oxepane Scaffolds through a Chalcogen Bonding Catalyzed Strain-Release C-Septanosylation Strategy

28) C. C. J. Loh* Chem. Catal. 2024, 4, 100980. (invited contribution to highlight Prof. Gang He's work in glycosylidene carbenes)

Taming Glycosylidene Carbenes through Bench-stable Glycosylidene Diaziridines to access Boro-Ketosides

27) C. Wang, A. Krupp, C. Strohmann, B. Grabe, C. C. J. Loh* J. Am. Chem. Soc. 2024, 146, 10608-10620.

Harnessing Multistep Chalcogen Bonding Activation in the α‑Stereoselective Synthesis of Iminoglycosides

26) H. Guo, J-L. Kirchhoff, C. Strohmann, B. Grabe, C. C. J. Loh* Angew. Chem. Int. Ed. 2024, 63, e202400912.

Asymmetric Pd/Organoboron-Catalyzed Site-Selective Carbohydrate Functionalization with Alkoxyallenes Involving Noncovalent Stereocontrol.

25) C. C. J. Loh* Chem. Catal. 2024, 4, 100891. (invited)

Synergistic catalysis: An emerging concept for selective carbohydrate synthesis.

In this perspective, Charles discuss his views pertaining to the renaissance of the synthetic-discovery-centered paradigm in stereoselective carbohydrate synthesis through emerging catalytic concepts such as synergistic catalysis.

24) H. Guo, J-L. Kirchhoff, C. Strohmann, B. Grabe, C. C. J. Loh* Angew. Chem. Int. Ed. 2024, 63, e202316667.

Exploiting π and Chalcogen Interactions for the β-Selective Glycosylation of Indoles through Glycal Conformational Distortion.

23) W. Ma, J-L. Kirchhoff, C. Strohmann, B. Grabe, C. C. J. Loh*  J. Am. Chem. Soc. 2023, 145, 26611-26622.

Cooperative Bifurcated Chalcogen Bonding and Hydrogen bonding as Stereocontrolling Elements for Selective Strain-Release Septanosylation.

22) V. U. Bhaskara Rao,^† C. Wang,^† D. P. Demarque, C. Grassin, F. Otte, C. Merten, C. Strohmann, C. C. J. Loh* Nat. Chem. 2023, 15, 424-435.

^†Authors contributed equally

A Synergistic Rh(I)/Organoboron Catalyzed Site Selective Carbohydrate Functionalization that involves Multiple Stereocontrol.

Highlighted by X-MOL (link)
Highlighted by "化学加" (link)

21) C. C. J. Loh*, Nat. Rev. Chem. 2021, 5, 792-815.
Exploiting Non-Covalent Interactions in Selective Carbohydrate Synthesis.

View only version link

20) C. Xu, V. U. Bhaskara Rao, J. Weigen, C. C. J. Loh*, Nat. Commun. 2020, 11, 4911.
A Robust and Tunable Halogen Bond Organocatalyzed 2-Deoxyglycosylation Involving Quantum Tunneling.

19) C. Xu, C. C. J. Loh*, J. Am. Chem. Soc. 2019, 141, 5381-5391.
A Multi-stage Halogen Bond Catalyzed Strain-Release Glycosylation unravels New Hedgehog Signaling Inhibitors.
- Highlighted in Synfacts 2019, 15, 0666, Contributors B. List, M. Turberg
- Highlighted in Nachrichten aus der Chemie 2020, 68, 42-72.

18) C. Xu, C. C. J. Loh*, Nat. Commun. 2018, 9, 4057.
An ultra-low thiourea catalyzed strain-release glycosylation and a multicatalytic diversification strategy.

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Before Independent Career (RWTH Aachen and University of Toronto)

17) A. Yen, K-L. Choo, S. K. Yazdi, P. T. Franke, R. Webster, I. Franzoni, C. C. J. Loh, A. I. Poblador-Bahamonde, M. Lautens*, Angew. Chem. Int. Ed. 2017, 56, 6307-6311
Rhodium-Catalyzed Enantioselective Isomerization of Meso-Oxabenzonorbornadienes to 1,2-Napthalene Oxides

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16) C. C. J. Loh, M. Schmid, R. Webster, A. Yen, S. K. Yazdi, P. T. Franke, M. Lautens*, Angew. Chem. Int. Ed. 2016, 55, 10074-10078.
Rhodium Catalyzed Asymmetric Cycloisomerization and A Parallel Kinetic Resolution of Racemic Oxabicycles.
(Highlighted in Synfacts 2017, 13, 0174, Contributors H. Yamamoto, H. Tsuji)

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15) C. C. J. Loh, M. Schmid, B. Peters, X. Fang, M. Lautens*, Angew. Chem. Int. Ed. 2016, 55, 4600-4604.
Exploiting Distal Reactivity of Coumarins: A Rhodium Catalyzed Vinylogous Asymmetric Ring Opening Reaction.
(Highlighted in Synfacts 2016, 12, 0719, Contributors H. Yamamto, F. Zhou)

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14) C. C. J. Loh, X. Fang, B. Peters, M. Lautens*, Chem. Eur. J. 2015, 21, 13883-13887.
Benzylic Functionalization of Anthrones via the Asymmetric Ring Opening of Oxabicycles utilizing a Fourth Generational Rhodium Catalytic System.
(Highlighted in Synfacts 2015, 11, 1286, Contributors H. Yamamoto, F. Zhou)

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13) S. Mahajan, P. Chauhan, C. C. J. Loh, S. Uzungelis, G. Raabe, D. Enders*, Synthesis 2015, 47, 1024-1031.
Organocatalytic Asymmetric Domino Michael/Henry Reaction of Indolin-3-ones with o-Formyl-b-nitrostyrenes.

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12) P. Chauhan, S. Mahajan, C. C. J. Loh, G. Raabe, D. Enders*, Org. Lett. 2014, 16, 2954-2957.
Stereocontrolled Construction of Six Vicinal Stereogenic Centers on Spiropyrazolones via Organocascade Michael/Michael/1,2-Addition Reactions.

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11) D. Hack, C. C. J. Loh, J. M. Hartmann, G. Raabe, D. Enders*, Chem. Eur. J. 2014, 20, 3917-3921.
Merging Gold and Organocatalysis: A Facile Asymmetric Synthesis of Annulated Pyrroles.

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10) C. C. J. Loh, P. Chauhan, D. Hack, C. Lehmann, D. Enders*, Adv. Synth. Catal. 2014, 356, 3181-3186.
Rapid Asymmetric Synthesis of Highly Functionalized Indanols via a Michael/Henry Organocascade with Submol% Squaramide Catalyst Loadings.

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9) Q. Ni, H. Zhang, A. Grossmann, C. C. J. Loh, C. Merkens, D. Enders*, Angew. Chem. Int. Ed. 2013, 52, 13562-13566.
Asymmetric Synthesis of Pyrroloindolones via N-Heterocyclic Carbene Catalyzed [2+3]-Annulation of α-Chloroaldehydes with Nitrovinylindoles.

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8) C. C. J. Loh, D. Hack, D. Enders*, Chem. Commun. 2013, 49, 10230-10232
Asymmetric Domino Synthesis of Indanes bearing Four Contiguous Stereocentres catalyzed by Sub-mol% Loadings of a Squaramide in Minutes.

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7) C. C. J. Loh, I. Atodiresei, D. Enders*, Chem. Eur. J. 2013, 19, 10822-10826.
Asymmetric Organocatalytic Michael/ Henry Domino Reactions through Hydrogen Bond Activation: A Kinetic Access into Indane Scaffolds Bearing cis-vicinal Substituents.

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6) J.-P. Wan, C. C. J. Loh, F. Pan, D. Enders*, Chem. Commun. 2012, 48, 10049-10051.
Enantioselective Organocatalytic Domino Synthesis of Tetrahydropyridin-2-ols.

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5) C. Wang, X. Yang, C. C. J. Loh, D. Enders*, Chem. Eur. J. 2012, 18, 11531-11535.
Organocatalytic, Asymmetric Synthesis of 3-Sulfenylated N-Boc-Protected Oxindoles.

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4)  C. C. J. Loh, G. Raabe, D. Enders*, Chem. Eur. J. 2012, 18,  13250-13254.
Enantioselective Synthesis of Tetrahydrocarbazoles Through a Michael Addition/ Ciamician-Plancher Rearrangement Sequence. Asymmetric Synthesis of a Potent Constrained Analog of MS-245.

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3) C. C. J. Loh, D. Enders*, Chem. Eur. J. 2012, 18, 10212-10225.
Merging Organocatalysis and Gold Catalysis—A Critical Evaluation of the Underlying Concepts. (Minireview) (Special conference issue for 4^th Chemistry European Congress, invited)

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2) C. C. J. Loh, D. Enders*, Angew. Chem. Int. Ed. 2012, 51, 46-48.
Exploiting the Electrophilic Properties of Indole Intermediates: New Options in Designing Asymmetric Reactions.

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1) C. C. J. Loh, J. Badorrek, G. Raabe, D. Enders*, Chem. Eur. J. 2011, 17, 13409-13414.
Merging Organocatalysis and Gold Catalysis: Enantioselective Synthesis of Tetracyclic Indole Derivatives through a Sequential Double Friedel–Crafts Type Reaction.
(Highlighted in Synfacts 2012, 8(1), 97, Contributors B. List, M. Mahlau).

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