Publications List

Independent Career

29) W. Ma, A. Schmidt, C. Strohmann, C. C. J. Loh* Angew. Chem. Int. Ed. 2024, DOI: 10.1002/anie.202405706
(Selected as Hot Paper in Angew. Chem.)

Stereoselective Entry into α,α’-C-Oxepane Scaffolds through a Chalcogen Bonding Catalyzed Strain-Release C-Septanosylation Strategy

28) C. C. J. Loh* Chem. Catal. 2024, 4, 100980. (invited contribution to highlight Prof. Gang He's work in glycosylidene carbenes)

Taming Glycosylidene Carbenes through Bench-stable Glycosylidene Diaziridines to access Boro-Ketosides

27) C. Wang, A. Krupp, C. Strohmann, B. Grabe, C. C. J. Loh* J. Am. Chem. Soc. 2024, 146, 10608-10620.

Harnessing Multistep Chalcogen Bonding Activation in the α‑Stereoselective Synthesis of Iminoglycosides

26) H. Guo, J-L. Kirchhoff, C. Strohmann, B. Grabe, C. C. J. Loh* Angew. Chem. Int. Ed. 2024, 63, e202400912.

Asymmetric Pd/Organoboron-Catalyzed Site-Selective Carbohydrate Functionalization with Alkoxyallenes Involving Noncovalent Stereocontrol.

25) C. C. J. Loh* Chem. Catal. 2024, 4, 100891. (invited)

Synergistic catalysis: An emerging concept for selective carbohydrate synthesis.

In this perspective, Charles discuss his views pertaining to the renaissance of the synthetic-discovery-centered paradigm in stereoselective carbohydrate synthesis through emerging catalytic concepts such as synergistic catalysis.

24) H. Guo, J-L. Kirchhoff, C. Strohmann, B. Grabe, C. C. J. Loh* Angew. Chem. Int. Ed. 2024, 63, e202316667.

Exploiting π and Chalcogen Interactions for the β-Selective Glycosylation of Indoles through Glycal Conformational Distortion.

23) W. Ma, J-L. Kirchhoff, C. Strohmann, B. Grabe, C. C. J. Loh*  J. Am. Chem. Soc. 2023, 145, 26611-26622.

Cooperative Bifurcated Chalcogen Bonding and Hydrogen bonding as Stereocontrolling Elements for Selective Strain-Release Septanosylation.

22) V. U. Bhaskara Rao, C. Wang, D. P. Demarque, C. Grassin, F. Otte, C. Merten, C. Strohmann, C. C. J. Loh* Nat. Chem. 2023, 15, 424-435.

Authors contributed equally

A Synergistic Rh(I)/Organoboron Catalyzed Site Selective Carbohydrate Functionalization that involves Multiple Stereocontrol.

Highlighted by X-MOL (link)
Highlighted by "化学加" (link)

21) C. C. J. Loh*, Nat. Rev. Chem. 2021, 5, 792-815.
Exploiting Non-Covalent Interactions in Selective Carbohydrate Synthesis.

View only version link

20) C. Xu, V. U. Bhaskara Rao, J. Weigen, C. C. J. Loh*, Nat. Commun. 2020, 11, 4911.
A Robust and Tunable Halogen Bond Organocatalyzed 2-Deoxyglycosylation Involving Quantum Tunneling.

19) C. Xu, C. C. J. Loh*, J. Am. Chem. Soc. 2019, 141, 5381-5391.
A Multi-stage Halogen Bond Catalyzed Strain-Release Glycosylation unravels New Hedgehog Signaling Inhibitors.
- Highlighted in Synfacts 2019, 15, 0666, Contributors B. List, M. Turberg
- Highlighted in Nachrichten aus der Chemie 2020, 68, 42-72.

XB Strain Release

18) C. Xu, C. C. J. Loh*, Nat. Commun. 2018, 9, 4057.
An ultra-low thiourea catalyzed strain-release glycosylation and a multicatalytic diversification strategy.


Before Independent Career (RWTH Aachen and University of Toronto)

17) A. Yen, K-L. Choo, S. K. Yazdi, P. T. Franke, R. Webster, I. Franzoni, C. C. J. Loh, A. I. Poblador-Bahamonde, M. Lautens*, Angew. Chem. Int. Ed. 2017, 56, 6307-6311
Rhodium-Catalyzed Enantioselective Isomerization of Meso-Oxabenzonorbornadienes to 1,2-Napthalene Oxides

TOC - Andy Yen ACIE

16) C. C. J. Loh, M. Schmid, R. Webster, A. Yen, S. K. Yazdi, P. T. Franke, M. Lautens*, Angew. Chem. Int. Ed. 201655, 10074-10078.
Rhodium Catalyzed Asymmetric Cycloisomerization and A Parallel Kinetic Resolution of Racemic Oxabicycles.
(Highlighted in Synfacts 2017, 13, 0174, Contributors H. Yamamoto, H. Tsuji)

Publication 16

15) C. C. J. Loh, M. Schmid, B. Peters, X. Fang, M. Lautens*, Angew. Chem. Int. Ed. 2016, 55, 4600-4604.
Exploiting Distal Reactivity of Coumarins: A Rhodium Catalyzed Vinylogous Asymmetric Ring Opening Reaction.
(Highlighted in Synfacts 2016, 12, 0719, Contributors H. Yamamto, F. Zhou)

Publication 15

14) C. C. J. Loh, X. Fang, B. Peters, M. Lautens*, Chem. Eur. J. 2015, 21, 13883-13887.
Benzylic Functionalization of Anthrones via the Asymmetric Ring Opening of Oxabicycles utilizing a Fourth Generational Rhodium Catalytic System.
(Highlighted in Synfacts 2015, 11, 1286, Contributors H. Yamamoto, F. Zhou)

Publication 14

13) S. Mahajan, P. Chauhan, C. C. J. Loh, S. Uzungelis, G. Raabe, D. Enders*, Synthesis 2015, 47, 1024-1031.
Organocatalytic Asymmetric Domino Michael/Henry Reaction of Indolin-3-ones with o-Formyl-b-nitrostyrenes.

Publication 13

12) P. Chauhan, S. Mahajan, C. C. J. Loh, G. Raabe, D. Enders*, Org. Lett. 2014, 16, 2954-2957.
Stereocontrolled Construction of Six Vicinal Stereogenic Centers on Spiropyrazolones via Organocascade Michael/Michael/1,2-Addition Reactions.

Publication 12

11) D. Hack, C. C. J. Loh, J. M. Hartmann, G. Raabe, D. Enders*, Chem. Eur. J. 2014, 20, 3917-3921.
Merging Gold and Organocatalysis: A Facile Asymmetric Synthesis of Annulated Pyrroles.

Publication 11

10) C. C. J. Loh, P. Chauhan, D. Hack, C. Lehmann, D. Enders*, Adv. Synth. Catal. 2014, 356, 3181-3186.
Rapid Asymmetric Synthesis of Highly Functionalized Indanols via a Michael/Henry Organocascade with Submol% Squaramide Catalyst Loadings.

Publication 10

9) Q. Ni, H. Zhang, A. Grossmann, C. C. J. Loh, C. Merkens, D. Enders*, Angew. Chem. Int. Ed. 2013, 52, 13562-13566.
Asymmetric Synthesis of Pyrroloindolones via N-Heterocyclic Carbene Catalyzed [2+3]-Annulation of α-Chloroaldehydes with Nitrovinylindoles.
Publication 9

8) C. C. J. Loh, D. Hack, D. Enders*, Chem. Commun. 2013, 49, 10230-10232
Asymmetric Domino Synthesis of Indanes bearing Four Contiguous Stereocentres catalyzed by Sub-mol% Loadings of a Squaramide in Minutes.

Publication 8

7) C. C. J. Loh, I. Atodiresei, D. Enders*, Chem. Eur. J. 2013, 19, 10822-10826.
Asymmetric Organocatalytic Michael/ Henry Domino Reactions through Hydrogen Bond Activation: A Kinetic Access into Indane Scaffolds Bearing cis-vicinal Substituents.

Publication 7

6) J.-P. Wan, C. C. J. Loh, F. Pan, D. Enders*, Chem. Commun. 2012, 48, 10049-10051.
Enantioselective Organocatalytic Domino Synthesis of Tetrahydropyridin-2-ols.

Publication 6

5) C. Wang, X. Yang, C. C. J. Loh, D. Enders*, Chem. Eur. J. 2012, 18, 11531-11535.
Organocatalytic, Asymmetric Synthesis of 3-Sulfenylated N-Boc-Protected Oxindoles.

Publication 5

4)  C. C. J. Loh, G. Raabe, D. Enders*, Chem. Eur. J. 2012, 18,  13250-13254.
Enantioselective Synthesis of Tetrahydrocarbazoles Through a Michael Addition/ Ciamician-Plancher Rearrangement Sequence. Asymmetric Synthesis of a Potent Constrained Analog of MS-245.

Publication 4

3) C. C. J. Loh, D. Enders*, Chem. Eur. J. 2012, 18, 10212-10225.
Merging Organocatalysis and Gold Catalysis—A Critical Evaluation of the Underlying Concepts. (Minireview) (Special conference issue for 4th Chemistry European Congress, invited)

Publicatoin 3

2) C. C. J. Loh, D. Enders*, Angew. Chem. Int. Ed. 2012, 51, 46-48.
Exploiting the Electrophilic Properties of Indole Intermediates: New Options in Designing Asymmetric Reactions.

Publication 2

1) C. C. J. Loh, J. Badorrek, G. Raabe, D. Enders*, Chem. Eur. J. 2011, 17, 13409-13414.
Merging Organocatalysis and Gold Catalysis: Enantioselective Synthesis of Tetracyclic Indole Derivatives through a Sequential Double Friedel–Crafts Type Reaction.
(Highlighted in Synfacts 2012, 8(1), 97, Contributors B. List, M. Mahlau).

Publication 1