LOH Research Group @
30th November 2023
Check out our latest contribution in another successful collaboration with the Strohmann's group in the use of bifurcated chalcogen bonding and hydrogen bonding for selective septanoside synthesis in JACS! Link
Great job by Wenpeng in unearthing the utility of chalcogen bonding catalysis in synthesizing challenging 7-ring sugars stereoselectively.
30th December 2022
A fantastic way to end 2022! Our group, in successful collaboration with the Merten's group and the Strohmann's group, disclose a chiral Rh(I)/organoboron site selective carbohydrate functionalization that involves a wide spectrum of stereocontrol, in Nature Chemistry.Link
A big shout out to the two heroic joint first-authors, Rao and Caiming who achieved this phenomenal feat during the difficult COVID-19 years.
See MPI Dortmund press release Link
6th September 2021
Our latest review depicting the exploitation of non-covalent interactions in selective carbohydrate chemistry as an emerging theme in contemporary carbohydrate chemistry is published in Nature Reviews Chemistry! Link
See MPI Dortmund press release Link
1st July 2021
The Loh research group thanks the Boehringer Ingelheim Foundation for a generous 900,000 Euros funding for supporting our exploration into utilizing unconventional noncovalent interactions in selective carbohydrate synthesis!
30th September 2020
Our latest publication in Nature Communications depicts the power of XB catalysis to elicit quantum tunneling in the rate determining proton transfer step of 2-deoxyglycosylations. Check it out! Link
8th March 2019
Our research demonstrating the first case of a multi-stage halogen bond (XB) catalyzed strain-release glycosylation which unravels non-SMO Hedgehog signaling inhibitors is currently online in JACS! Link
3rd October 2018
Our research group's first independent paper is published currently in Nature Communications! Link
Impressive job by Chunfa for the superb effort spearheading strain-release glycosylations using ultra-low loadings of thiourea.
We are a dynamic research group situated at the the Max Planck Institut für Molekulare Physiologie and are co-affiliated with the Technical University of Dortmund. Currently, we are actively involved in developing innovative catalytic solutions to address fundamental selectivity challenges in carbohydrate chemistry, and are very enthusiastic in cross-disciplinary fields involving mechanistic DFT computations and chemical biology. For more information on our research, check out our research interest page.
We are always seeking for enthusiastic organic/computational chemists or chemical biologists seeking to further their doctoral studies or their post-doctoral research in an exciting and challenging environment. Our group deeply values diversity, equity, inclusion and access, which we believe is fundamental for innovation and scientific progress. Hence, we particularly invite candidates from underrepresented groups to join us!
Do you think you have an exceptional aptitude for out-of-the-box thinking and aspire to revolutionize modern synthetic methodologies with a multidisciplinary outlook? If you are interested in embarking on this adventurous research endeavour with us, feel free to contact Dr. Charles Loh for more information.
For research profile of Dr. Charles Loh, see:
The following funding agencies are gratefully acknowledged for generous funding :
We also gratefully thank the following industrial partners for generous donations in supporting our frontier research: