LOH Research Group @
Newsflash!
10th November 2024
The Loh research group has successfully shifted to University College Dublin in Ireland after 8 fruitful years in Dortmund!
We are extremely excited to continue our journey in using novel catalytic platforms to tackle long-standing stereoselectivity problems in carbohydrate synthesis!
Check out our recent Angewandte work in the seminal use of chiral radical catalysis to address the site-selectivity challenge in carbohydrate etherifications: Link
30th April 2024
Another intriguing example by Wenpeng in exploiting chalcogen bonding (ChB) catalysis for α,α’-C-Oxepane scaffold synthesis in Angewandte: Link
We are immensely excited by the unprecedented opportunities offered by ChB catalysis in stereoselective carbohydate synthesis!
2nd April 2024
Check out our new exciting developments in unraveling the impact of noncovalent interactions in stereoselective carbohydrate synthesis!
- Caiming Wang's PhD work in the usage of chalcogen bonding activation in accessing iminoglycosides in JACS: Link
- Hao Guo's demonstration that noncovalent interactions are pivotal in stereoselectivity control in transition metal catalyzed site-selective functionalization of carbohydrate polyols in Angewandte: Link
27th February 2024
Want to get to know Charles up close? Check out the latest Angewandte "Introducing" Profile of Charles to get a glimpse of the personal side of Charles!
Link
20th December 2023
Ending 2023 with a toast! Congrats Hao Guo for unraveling the amazing capability of chalcogen bonding and π-interactions to distort the conformation of glycals for effective β-glycosylation with indoles in Angewandte Chemie. Cheers to our collaborators at the Strohmann's group for ending the year with a blast! Link
See MPI Dortmund press release Link
30th November 2023
Check out our latest contribution in another successful collaboration with the Strohmann's group in the use of bifurcated chalcogen bonding and hydrogen bonding for selective septanoside synthesis in JACS! Link
Great job by Wenpeng in unearthing the utility of chalcogen bonding catalysis in synthesizing challenging 7-ring sugars stereoselectively.
See MPI Dortmund press release Link
30th December 2022
A fantastic way to end 2022! Our group, in successful collaboration with the Merten's group and the Strohmann's group, disclose a chiral Rh(I)/organoboron site selective carbohydrate functionalization that involves a wide spectrum of stereocontrol, in Nature Chemistry.Link
A big shout out to the two heroic joint first-authors, Rao and Caiming who achieved this phenomenal feat during the difficult COVID-19 years.
See MPI Dortmund press release Link
6th September 2021
Our latest review depicting the exploitation of non-covalent interactions in selective carbohydrate chemistry as an emerging theme in contemporary carbohydrate chemistry is published in Nature Reviews Chemistry! Link
See MPI Dortmund press release Link
1st July 2021
The Loh research group thanks the Boehringer Ingelheim Foundation for a generous 900,000 Euros funding for supporting our exploration into utilizing unconventional noncovalent interactions in selective carbohydrate synthesis!
Boehringer Ingelheim Foundation announcement English German
See MPI Dortmund press release English German
30th September 2020
Our latest publication in Nature Communications depicts the power of XB catalysis to elicit quantum tunneling in the rate determining proton transfer step of 2-deoxyglycosylations. Check it out! Link
8th March 2019
Our research demonstrating the first case of a multi-stage halogen bond (XB) catalyzed strain-release glycosylation which unravels non-SMO Hedgehog signaling inhibitors is currently online in JACS! Link
3rd October 2018
Our research group's first independent paper is published currently in Nature Communications! Link
Impressive job by Chunfa for the superb effort spearheading strain-release glycosylations using ultra-low loadings of thiourea.
We are a dynamic research group situated at the the Max Planck Institut für Molekulare Physiologie and are co-affiliated with the Technical University of Dortmund. Currently, we are actively involved in developing innovative catalytic solutions to address fundamental selectivity challenges in carbohydrate chemistry, and are very enthusiastic in cross-disciplinary fields involving mechanistic DFT computations and chemical biology. For more information on our research, check out our research interest page.
We are always seeking for enthusiastic organic/computational chemists or chemical biologists seeking to further their doctoral studies or their post-doctoral research in an exciting and challenging environment. Our group deeply values diversity, equity, inclusion and access, which we believe is fundamental for innovation and scientific progress. Hence, we particularly invite candidates from underrepresented groups to join us!
Do you think you have an exceptional aptitude for out-of-the-box thinking and aspire to revolutionize modern synthetic methodologies with a multidisciplinary outlook? If you are interested in embarking on this adventurous research endeavour with us, feel free to contact Dr. Charles Loh for more information.
For research profile of Dr. Charles Loh, see:
The following funding agencies are gratefully acknowledged for generous funding :
We also gratefully thank the following industrial partners for generous donations in supporting our frontier research:
